No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin loci KM or GM

✍ Scribed by Dr. L. Leigh Field; Alisa Goldstein; M. Anne Spence; C. E. Anderson; David L. Rimoin; D. C. Rao

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 507 KB
• Volume: 1
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370010409

✦ Synopsis

We studied 52 families having more than one member affected with insulindependent diabetes mellitus (IDDM) for linkage of an IDDM-susceptibility locus to the immunoglobulin loci KM and GM. Linkage was analyzed by the LOD score method using single-locus recessive and dominant models of IDDM inheritance, with penetrances of the disease-susceptible genotypes being dependent on age and reaching a maximum of 20% by age 40. We found no evidence for linkage of IDDM to KM or GM. Close linkage (recombination fraction < 5%) was rejected for KM under the recessive model and for GM under both models. These results suggest either that there are no IDDM-susceptibility loci closely linked to KM or GM or that use of a single-locus model of IDDM (which ignores the effects of the susceptibility locus in the HLA region) is inadequate for their detection.