Investigating Direct Alkynylation at the Bridgehead of Bicyclic Cages Using Silver(I) Acetylides

✍ Scribed by Rebecca H. Pouwer; Jason B. Harper; Kamesh Vyakaranam; Josef Michl; Craig M. Williams; Carsten H. Jessen; Paul V. Bernhardt

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 186 KB
• Volume: 2007
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200600701

✦ Synopsis

Abstract

Silver(I) acetylides facilitate direct carbon–carbon bond formation at the bridgehead position of adamantane, and in some instances related systems such as carborate anions and bicyclo[2.2.2]octanes. Substrate constraints along with attempts to further understand the underlying mechanism are presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)