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Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study

Book ID
123193605
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
135 KB
Volume
15
Category
Article
ISSN
0169-5002

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Cdk4-mediated phosphorylation of Rb protein is inhibited by pl6, a product of a possible tumor suppressor gene. We examined the expression of p16 and Rb protein by means of immunohistochemistry in 61 non-small cell lung cancers and have demonstrated an inverse relationship between the expression of

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In order to clarify the frequency of p16 gene inactivation and its relationship with Rb expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 paraffin-embedded sections of primary non-small cell lung cancers (NSCLCs). From immunohistochemical results, abnormal p16 exp