𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study

✍ Scribed by Masahiro Sakaguchi; Yoshitaka Fujii; Hirohisa Hirabayashi; Hyung-Eun Yoon; Yosuke Komoto; Takaharu Oue; Takeshi Kusafuka; Akira Okada; Hikaru Matsuda

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
469 KB
Volume
65
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Cdk4-mediated phosphorylation of Rb protein is inhibited by pl6, a product of a possible tumor suppressor gene. We examined the expression of p16 and Rb protein by means of immunohistochemistry in 61 non-small cell lung cancers and have demonstrated an inverse relationship between the expression of p I 6 and Rb protein: 28/30 specimens that did not stain for p i 6 stained for Rb and 2 I /3 I p 16-positive specimens did not stain for Rb. Only I of the pl6-negative specimens had a mutation of exon 2 of the CDKN2 gene. Our results indirectly

πŸ“œ SIMILAR VOLUMES

Correlation between methylation status o
Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers
✍ Kenji Kashiwabara; Tetsunari Oyama; Takaaki Sano; Toshio Fukuda; Takashi Nakajim πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 423 KB πŸ‘ 1 views

In order to clarify the frequency of p16 gene inactivation and its relationship with Rb expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 paraffin-embedded sections of primary non-small cell lung cancers (NSCLCs). From immunohistochemical results, abnormal p16 exp

Expression of p16 and lack of pRB in pri
Expression of p16 and lack of pRB in primary small cell lung cancer
✍ Yuan, Juping; Knorr, JοΏ½rgen; Altmannsberger, Michael; Goeckenjan, Gerd; Ahr, And πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 300 KB πŸ‘ 1 views

The retinoblastoma protein (pRB), p16, and cyclin D1 are major components of the RB pathway, which controls the G1 checkpoint of the cell cycle. Proper regulation of this pathway is crucial for normal cell proliferation. Abnormal forms of these proteins have been found in various types of malignant

Quantitative analysis of p53 protein in
Quantitative analysis of p53 protein in non-small cell lung cancer and its prognostic value
✍ Michael A. Levesque; Mario D'Costa; Ernest H. Spratt; Mohammad M. Yaman; Elefthe πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 99 KB πŸ‘ 1 views

Accumulation of mutant p53 protein occurs frequently in human malignancies, including 40-60% of non-small cell lung carcinomas. The implications of such p53 over-expression, usually assessed by immunohistochemical techniques, for the prognosis of lung cancer patients remain undetermined. In this stu

Alterations of expression of Rb, p16INK4
Alterations of expression of Rb, p16INK4A and cyclin D1 in non-small cell lung carcinoma and their clinical significance
✍ Brambilla, Elisabeth; Moro, Denis; Gazzeri, Sylvie; Brambilla, Christian πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 313 KB πŸ‘ 2 views

## Inactivation of the Rb pathway in non-small cell lung carcinoma (NSCLC) occurs mostly through inactivation of the cyclin-dependent kinase inhibitor p16 INK4A and/or up-regulation of cyclin D1. In order to assess the frequency and the prognostic value of these abnormalities in NSCLC, immunohisto