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Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

✍ Scribed by Teyton, Luc; O'Sullivan, Deirdre; Dickson, Phillip W.; Lotteau, Vincent; Sette, Alessandro; Fink, Pamela; Peterson, Per A.


Book ID
109766351
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
856 KB
Volume
348
Category
Article
ISSN
0028-0836

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## Abstract The MHC class II‐associated invariant chain (Ii) has several important functions in antigen presentation. In this study, we have examined the effect of Iip33 expression on endocytic transport and antigen presentation. We find that degradation of both endocytosed antigen and Ii itself is