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Invariant Chain Dissociation from Class II MHC Is a Catalyst for Foreign Peptide Binding

✍ Scribed by V. E. REYES; M. DAIBATA; R. ESPEJO; R. E. HUMPHREYS


Book ID
119870964
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
573 KB
Volume
730
Category
Article
ISSN
0890-6564

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Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e