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Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

✍ Scribed by Richard J Riese; Paula R Wolf; Dieter Brömme; Lisa R Natkin; José A Villadangos; Hidde L Ploegh; Harold A Chapman


Book ID
117722657
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
315 KB
Volume
4
Category
Article
ISSN
1074-7613

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Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e