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Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

✍ Scribed by Metzler, M; Staege, M S; Harder, L; Mendelova, D; Zuna, J; Fronkova, E; Meyer, C; Flohr, T; Bednarova, D; Harbott, J

Book ID
109886790
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
283 KB
Volume
22
Category
Article
ISSN
0887-6924

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We report on an adult patient with de novo acute myeloid leukemia (AML) with a t(11;22)(q23;q11.2) involving CDCREL1 and MLL genes. Reverse transcriptase (RT)-polymerase chain reaction (PCR) followed by direct sequencing analysis revealed the MLL-CDCREL1 fusion transcript in his leukemic cells. Anal