Introduction of an integrated multiple-instrument LC system

✍ Scribed by M. Tesanovic

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 117 KB
• Volume: 27
• Category: Article
• ISSN: 0009-9120
• DOI: 10.1016/0009-9120(94)90078-7

✦ Synopsis

should be assayed by a less costly less specific immunoinhibition assay (Hitachi 717) or by a more costly more specific immunoenzymatic assay (Tandem ICON QSR). Key elements of the algorithm are: 1. CK, AST and ALT are available on demand. 2. CK-MB (Hitachi 717) is available only when CK > reference range or ACK >50 and CK-MB not previously positive for MI (>35 U/L + >5%) within last 48 h. 3. CK-MB (Tandem ICON QSR) is available only when atypical-CK or CK-BB interference of CK-MB (Hitachi 717) assay is suspected. That is when CK-MB (Hitachi 717/CK >24% or >18% plus CK/AST > 12 and AST/ALT <2 and CK-MB not previously positive for MI (>7 ng/ml + >1.5%) within last 48 h. This approach has been modeled and compared to other testing strategies on a patient database of about 3000 specimens submitted to the lab for investigation of MI. It was found to outperform all other alternative schemes in that it achieved highest possible sensitivity and specificity for a final diagnosis of MI at lowest cost.