✦ LIBER ✦

Intravascular thrombosis in skeletal muscle microcirculation after ischemia

✍ Scribed by Langdon A. Hartsock; Anthony V. Seaber; James R. Urbaniak

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 552 KB
Volume: 10
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.1920100303

No coin nor oath required. For personal study only.

✦ Synopsis

This study was undertaken to elucidate the role of thrombosis in blood vessels less than 0.1 mm in diameter in skeletal muscle after an ischemic episode.

Capillaries were examined after normothermic ischemia using intravital video microscopy of the cremaster muscle of an anesthetized rat. Histologic sections of the cremaster musde and silicone rubber intravascular casts were also analyzed. Our model demonstrates that, after 3 hours of warm ischemia, up to two-thirds of capillaries are clotted, as is most of the venous system. Our findings also indicate that capillaries may reopen during 30 minutes of reperfusion. These findings suggest that ischemia may cause thrombosis in the microvasculature of skeletal muscle but the thrombosis appears to be partially reversible.

📜 SIMILAR VOLUMES

Comparison of skeletal muscle microcircu

Comparison of skeletal muscle microcirculation between clamp ischemia and microsurgical ischemia

✍ Fu-Chan Wei; Yu-Cheng Chang; Yi-Hsuan Lee; Kwan-Cheng Wang; Jay Lee 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 459 KB

We compared ischemia reperfusion injury-associated vasospasm and perfused capillary density (PCD) at the microcirculatory level between clamp ischemia and microsurgical ischemia in rat skeletal muscle. Rat cremaster muscle was prepared as an island flap, attached only with pudic-epigastric vessels b

Changes in microcirculation after ischem

Changes in microcirculation after ischemic process in rat skeletal muscle

✍ Norbert Nemeth; Tamas Lesznyak; Endre Brath; Gabor Acs; Arpad Nagy; Jozsef Pap-S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

## Abstract Laser Doppler flowmetry (LDF) is a good method to investigate tissue microcirculation, but it has many standardization and measuring problems. To exclude these effects, we performed a test using LDF on rat skeletal muscle. In 12 CD outbred anesthetized rats, bilateral femoral vessels an

Studies of ischemia-reperfusion injury i

Studies of ischemia-reperfusion injury in skeletal muscle: Efficacy of 21-aminosteroids on microcirculation and muscle contraction after an extended period of warm ischemia

✍ Anastasios V. Korompilias; Long-En Chen; Anthony V. Seaber; James R. Urbaniak 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 591 KB

## Abstract The present study was conducted to elucidate the effects of tirilazad mesylate (U‐74006F), a potent inhibitor of lipid peroxidation, on vessel diameter, capillary perfusion, and contractile function of rat cremaster muscle during a 90‐minute reperfusion period that followed 4 hours of w

Combined effect of acute denervation and

Combined effect of acute denervation and ischemia on the microcirculation of skeletal muscle

✍ Long-En Chen; Anthony V. Seaber; James R. Urbaniak 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 802 KB

## Abstract Using direct in vivo videomicroscopy and a fluorescein dye technique, reperfusion injury after 3 h of ischemia was studied in the acutely denervated cremaster muscle of the rat. Compared with normally innervated controls, ischemia‐induced reperfusion injury was more severe in the denerv

Effects of supplementation of BH4 after

Effects of supplementation of BH4 after prolonged ischemia in skeletal muscle

✍ Wei Z. Wang; Xin-Hua Fang; Linda L. Stephenson; Kayvan T. Khiabani; William A. Z 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

## Abstract __Purpose:__ To determine whether the supplementation of tetrahydrobiopterin (BH~4~, an essential cofactor of nitric oxide synthase; NOS) could attenuate endothelial dysfunction and improve NOS activity and cell viability in skeletal muscle after ischemia/reperfusion (I/R). __Methods:__

Intermittent pneumatic compression of le

Intermittent pneumatic compression of legs increases microcirculation in distant skeletal muscle

✍ Kang Liu; Long-En Chen; Anthony V. Seaber; Glenn W. Johnson; James R. Urbaniak 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 770 KB

Intermittent pneumatic compression has bccn established as a method of clinically preventing deep vein thrombosis, but the mechanism has not been documented. This study observed the effects of intermittent pncumatic compression of legs on the microcirculation of distant skeletal muscle. The cremaste