## Abstract ## Background Highโgrade gliomas are highly lethal neoplasms representing approximately 20% of all intracranial tumors. Cationic liposomeโmediated interferonโbeta (__IFNโ__ฮฒ) gene transfer has been found to induce regression of experimental glioma. We have previously performed a pilot
Intratumor administration of beta-interferon in recurrent malignant gliomas. A phase I clinical and laboratory study
โ Scribed by Michael R. Fetell; Edgar M. Housepian; Martin W. Oster; Debra N. Cote; Michael B. Sisti; Stephen G. Marcus; Paul B. Fisher
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 595 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0008-543X
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Preclinical data suggest synergy of interleukin-2 (IL-2) combined with alphainterferon (IFN). In addition, toxicities of IL-2 may be decreased by intermittent continuous infusion. The purpose of this trial was to determine the maximum tolerated dose (MTD) of recombinant IL-2 combined with alpha-IFN
waves in combination with platinum-based chemotherapy in ten children and 4 Institute of Statistics, Heinrich-Heine Univeradolescents with recurrent or refractory GCTs. sity, Du ยจsseldorf, Germany. ## RESULTS. Seven of ten patients with recurrent or refractory GCTs had objective responses. Of the