Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration
β Scribed by D. Galimberti; E. Venturelli; C. Fenoglio; I. Guidi; C. Villa; L. Bergamaschini; F. Cortini; D. Scalabrini; P. Baron; C. Vergani; N. Bresolin; E. Scarpini
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 298 KB
- Volume
- 255
- Category
- Article
- ISSN
- 0340-5354
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Background One of the pathological hallmarks of Alzheimer's disease (AD) is deposits of amyloid Ξ²-peptide (AΞ²) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with AΞ² reduces AΞ² deposits and improves memory and learning deficits. Because recent clinical trials of immunizati