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Intrathecal baclofen for spasticity in primary lateral sclerosis

✍ Scribed by Hélio A.G. Teive


Publisher
Springer
Year
2007
Tongue
English
Weight
68 KB
Volume
254
Category
Article
ISSN
0340-5354

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CSF Baclofen levels after intrathecal ad
✍ B. Sallerin-Caute; Y. Lazorthes; B. Monsarrat; J. Cros; R. Bastide 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 283 KB

The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize