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Intraperitoneal therapy of ovarian cancer with retargeted lymphocytes by bispecific monoclonal antibodies and interleukin-2

โœ Scribed by A. M. M. Eggermont; S. H. Goey; A. Logmans; J. B. M. Z. Trimbos; S. O. Warnaar; F. J. Cleton; C. H. J. Lamers; R. L. H. Bolhuis; G. Stoter

Book ID
112792374
Publisher
Blackwell Publishing
Year
1995
Tongue
German
Weight
396 KB
Volume
27
Category
Article
ISSN
0001-544X

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๐Ÿ“œ SIMILAR VOLUMES

Local but no systemic immunomodulation b
Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re-targeted by a bi-specific monoclonal antibody
โœ Cor H.J. Lamers; Reinder L.H. Bolhuis; Sven O. Warnaar; Gerrit Stoter; Jan W. Gr ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 201 KB ๐Ÿ‘ 1 views

We have reported a 27% overall anti-tumor response using i.p. immunotherapy of advanced ovarian carcinoma with autologous, ex vivo expanded, T lymphocytes re-targeted with bi-specific monoclonal antibody OC/TR, combined with soluble OC/TR and low-dose recombinant interleukin-2 (IL-2). This treatment

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T lymphocytes of 8 patients with ovarian cancer were targeted to the tumor cells using F(ab')2 fragments of a bispecific monoclonal antibody (bsAb), specific for CD3 (a component of the T lymphocyte receptor for antigen) and for the folate receptor MOv I 8 (overexpressed by ovarian carcinoma cells)

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The proliferation of autologous tumor-reactive cytotoxic T lymphocytes (CTL), induced by autologous mixed lymphocyte tumor-cell culture, was remarkably enhanced by activation with immobilized anti-CD3 monoclonal antibody (MAb) and interleukin-2 (IL-2), as compared with IL-2 alone. The activated CTL