Intraperitoneal P-32 after negative second-look laparotomy in ovarian carcinoma

✍ Scribed by T. Rhett Spencer Jr.; Richard D. Marks Jr.; Jimmy O. Fenn; Joseph M. Jenrette III; Myrton H. Lutz

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 335 KB
• Volume: 63
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19890615)63:12<2434::aid-cncr2820631211>3.0.co;2-b

✦ Synopsis

Ikirty-one patients underwent a negative second-look laparotomy between 1976 and 1986. Fourteen patients received intraperitoneal chromic phosphate (P-32) after a negative second-look laparotomy. There has been no local recurrence (zero of 14) and no deaths attributable to recurrent disease. Local control and disease-free survival are loo%, with a minimum follow-up of 2 years and a mean follow-up of 4 years.

Seventeen patients received no further therapy because of patient refusal, poor diffusion, or other contraindications to P-32 installation. Four of 17 patients undergoing negative second-look procedures without the addition of P-32 have subsequently recurred. This difference is highly suggestive ( P = .076). There have been no major complications with the addition of P-32. The use of intraperitoneal P-32 after negative second-look laparotomies on ovarian carcinoma is well tolerated and effective in preventing recurrence.