Consolidative 32P after second-look laparotomy for ovarian carcinoma

✍ Scribed by Kellie S. Condra; William M. Mendenhall; Linda S. Morgan; Robert B. Marcus Jr.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 115 KB
• Volume: 6
• Category: Article
• ISSN: 1065-7541
• DOI: 10.1002/(sici)1520-6823(1998)6:2<97::aid-roi5>3.0.co;2-c

✦ Synopsis

We report our experience with consolidative 32 P after second-look laparotomy. Forty-three patients received consolidative 32 P after platinum-based chemotherapy and a negative (39 patients, 91%) or positive (4 patients) second-look laparotomy. Thirtyone patients (72%) initially had stage III (30 patients) or stage IV (1 patient) disease; 28 patients (65%) had grade 3 tumors. Patients had follow-up from 3.5 to 14.9 years (median, 7.7 years); no patient was lost to follow-up. The 5-year rates of control of disease within the abdomen (local control) for the overall group and the subset of patients with stage II-IV disease and a negative second-look laparotomy were 65% and 69%, respectively. The corresponding 5-year survival rates were 78 and 81%, respectively. Multivariate analyses revealed that tumor found at second-look laparotomy significantly influenced the likelihood of local control and cause-specific survival. Acute side effects included cellulitis (1 patient) and ileus (3 patients). Two patients (5%) experienced severe late complications; both experienced small bowel obstruction that necessitated surgical intervention. Consolidative 32 P appears to reduce the risk of recurrence and improve survival after negative second-look laparotomy. The risk of significant complications is low.