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Intraparenchymal administration of interleukin-1β induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain

✍ Scribed by Amy H. Moore; John A. Olschowka; M.Kerry O'Banion


Book ID
113729226
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
309 KB
Volume
148
Category
Article
ISSN
0165-5728

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## Abstract ## Objective Membrane‐associated prostaglandin E synthase (mPGES) is a recently identified terminal enzyme of the arachidonic acid cascade, which converts PGH~2~ to PGE~2~ in rheumatoid arthritis synovial fibroblasts (RASFs). This study was undertaken to investigate factors regulating