Exploring the importance of Richard F. Heck’s carbon coupling reaction, this book highlights the subject of the 2010 Nobel Prize in Chemistry for palladium-catalyzed cross couplings in organic synthesis, and includes a foreword from Nobel Prize winner Richard F. Heck. The Mizoroki-Heck reaction is
Intramolecular Mizoroki-Heck Reaction in the Regioselective Synthesis of 4-Alkylidene-tetrahydroquinolines
✍ Scribed by Martínez-Estíbalez, Unai; García-Calvo, Oihane; Ortiz-de-Elguea, Verónica; Sotomayor, Nuria; Lete, Esther
- Book ID
- 120330692
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 555 KB
- Volume
- 2013
- Category
- Article
- ISSN
- 1434-193X
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
The highly congested ABC-ring moiety of zoanthenol was stereoselectively synthesized via an alkoxylithium-mediated coupling between the A-ring and C-ring moieties followed by a Mizoroki-Heck-type ring closure.
## Abstract Acylation of the alkenes 1a–d and 3, easily prepared from the corresponding α‐amino acids, with 2‐iodobenzoyl chloride gives 2a–d and 4 which cyclize to the enantiopure dihydroisoquinolinones 5a–d and 9, resp., in an intramolecular Heck reaction using 5 mol‐ % of Pd(OAc)~2~ in the prese