Intramolecular double Michael reaction. Part II. Synthesis of isoatisirene type compound
✍ Scribed by Masataka Ihara; Masahiro Toyota; Keiichiro Fukumoto; Tetsuji Kametani
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 264 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The double Michael reaction between the acyclic cross‐conjugated dienones dibenzalacetone or divinyl ketone and cyclohexane‐1,3‐diones gives new, substituted spiro [5,5] undecane‐l,5,9‐triones. Some of these are reduced to the corresponding spirodiketone or monoketone.
An enantioselective synthesis of a 6oxygenated atisine derivative 20 is described. The atisine skeleton 18 was stereoselectively constructed by the intramolecular double Michael reaction of the enone ester 16. derived. through the al&hy& 3, from the symmetrical ketone 4. The diterpenoid alkaloids ha