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Intramolecular Diels-Alder reactions of 1,2,4-triazines: Synthesis of tricyclic condensed pyridines and pyrazines

✍ Scribed by Edward C. Taylor; Larry G. French

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 187 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84423-8

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✦ Synopsis

Syntheses of several 6,6,6-tricyclic condensed pyridines and pyrazines utilizing intramolecular Diels-Alder reactions of 1,2,4-triazines with alkyne and nitrile dienophiles are detailed. The cyclizations are facilitated by the presence 01 conformationally restrictive planar aromatic rings in the chain tethering the diene and the dienophile.

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