Intramolecular cycloaddition of nitrones with sulfur-substituted dienes and its synthetic applications
β Scribed by Shang-Shing P. Chou; Yu-Ju Yu
- Book ID
- 104257394
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 188 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Asefies of sulfur-substituted dienyl nitmnes wereconviently prepm'edfrom the 3sulfolene precursors, lntrsmolecular 1.3-dipolar cycloaddition reactions gave the fused bicyclic isoxazolidines.The regio-and stereochemicaloutcome of these reactions aswell as the synthetic applications have been explored.
π SIMILAR VOLUMES
The first aza-Diels-Alder reactions of arylsulfonyl isocyanates with thio-substituted 1,3-dienes via the 3-sulfolene precursors 1 gave the cyclized products 3 with complete control of regio-and chemoselectivity. The cyclized products 3a and 4 underwent further interesting reactions with nucleophiles
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