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Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model

โœ Scribed by Byron C. Masi; Betty M. Tyler; Hansen Bow; Robert T. Wicks; Yuan Xue; Henry Brem; Robert Langer; Michael J. Cima

Book ID
113492120
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
885 KB
Volume
33
Category
Article
ISSN
0142-9612

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Camptothecin, a naturally occurring inhibitor of the DNAreplicating enzyme topoisomerase I, demonstrated promising anti-tumor activity in pre-clinical testing; however, because of unexpected toxicity and low anti-tumor effects in the initial clinical trials, further testing was discontinued. We hypo