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Enhancement of cisplatin efficacy by thalidomide in a 9L rat gliosarcoma model

✍ Scribed by Susan Murphy; Ross A. Davey; Xiao-Qing Gu; Miriam C. Haywood; Lauren A. McCann; Laurence E. Mather; Frances M. Boyle


Book ID
106480812
Publisher
Springer US
Year
2007
Tongue
English
Weight
372 KB
Volume
85
Category
Article
ISSN
0167-594X

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Camptothecin, a naturally occurring inhibitor of the DNAreplicating enzyme topoisomerase I, demonstrated promising anti-tumor activity in pre-clinical testing; however, because of unexpected toxicity and low anti-tumor effects in the initial clinical trials, further testing was discontinued. We hypo