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Intraclonal competition limits the fate determination of regulatory T cells in the thymus

✍ Scribed by Bautista, Jhoanne L; Lio, Chan-Wang J; Lathrop, Stephanie K; Forbush, Katherine; Liang, Yuqiong; Luo, Jingqin; Rudensky, Alexander Y; Hsieh, Chyi-Song


Book ID
109920787
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
934 KB
Volume
10
Category
Article
ISSN
1529-2908

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Recent findings suggest that mature T cells in the thymus may regulate the growth and differentiation of immature thymocytes. Here we use mathematical modeling and computer simulations to identify the thymocyte subsets that might serve as targets for regulation, and the processes that might be affec