Gene regulatory networks and the determination of lymphoid cell fates

✍ Scribed by Harinder Singh; Jagan MR Pongubala

• Publisher: Elsevier Science
• Year: 2006
• Tongue: English
• Weight: 140 KB
• Volume: 18
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2006.01.014

✦ Synopsis

Considerable progress has been achieved in the identification and analysis of regulatory molecules that orchestrate B and T cell fate determination. IL-7 and Notch signaling appear to represent analogous pathways that direct B and T cell fates, respectively. For the B lineage, it is possible to assemble the various signaling components and transcription factors into a coherent gene regulatory network. At present, it is not possible to assemble an equivalently precise network for the T lineage as fewer components have been analyzed and their connectivity remains to be more fully explored. However, the ability to manipulate T cell development in a simple culture system using Notch ligand-expressing stromal cells is greatly facilitating analysis of this pathway.