Chromosomal band 3q27 exhibits recurring and nonrecurring translocations and other rearrangements in approximately 8% of B-cell non-Hodgkin lymphomas (NHL) belonging to low-grade as well as diffuse aggressive histologies. The BCL6 gene, which encodes a zinc-finger transcription repressor protein and
Intrachromosomal rearrangement of chromosome 3q27: an under recognized mechanism of BCL6 translocation in B-cell non–Hodgkin lymphoma
✍ Scribed by Christian Ernst Keller; Subhadra Nandula; Efsevia Vakiani; Bachir Alobeid; Vundavalli V. Murty; Govind Bhagat
- Book ID
- 116534208
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 182 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1532-8392
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The LAZ3(BCL6) gene on chromosome band 3q27 is nonrandomly disrupted in B-cell non-Hodgkin lymphoma (B-NHL) by chromosomal translocations clustered within a 3.3-kb MTC (major translocation cluster) located between the two first noncoding exons. These translocations generally result in the expression
Chromosomal band 3q27 frequently engages in translocations with a number of sites within the genome, including those containing IG and other genes, during the development of B-cell lymphoma. The BCL6 gene, mapped at 3q27, is deregulated in these translocations and was isolated from a t(3;14)(q27;q32