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Intracellular topography of succinic dehydrogenase in the thyroid of the albino rat

✍ Scribed by Goddard, J. W. ;Seligman, Arnold M.


Publisher
John Wiley and Sons
Year
1952
Tongue
English
Weight
835 KB
Volume
112
Category
Article
ISSN
0003-276X

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Brain succinate dehydrogenase (SDH) activity was inhibited by in vitro hexachlorophene (HCP) with a half inhibitory concentration (IC 50 ) of 0.65 ‫‬ 10 ‫3‬ M. The HCP exerted noncompetitive inhibition at 0.5 mM (Ο½IC 50 ), uncompetitive inhibition at 0.65 mM (IC 50 ), and mixed-type inhibition at 0.