✍ Scribed by Scott R. Macfarlane; Robin Plevin
No coin nor oath required. For personal study only.
The proteinase‐activated receptor (PAR) family are novel members of the G‐protein coupled receptor superfamily that are activated by a mechanism involving specific proteolytic cleavage of their N‐terminal. Activation of intracellular signalling pathways by the PAR family has received relatively little attention compared with the other aspects of their function. Along with activation of intracellular calcium, diacylglycerol, and inositol 1,4,5‐trisphosphate, PARs have been reported to activate signalling pathways closely linked to both cell proliferation and inflammation. Here we attempt to describe these signalling pathways and the G‐proteins involved in coupling the receptors to these intracellular events. Drug Dev. Res. 59:367–374, 2003. © 2003 Wiley‐Liss, Inc.
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