𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Intracellular localization of metaiodobenzyl guanidine in human neuroblastoma cells by electron spectroscopic imaging

✍ Scribed by M. N. Gaze; I. M. Huxham; R. J. Mairs; Ann Barrett

Book ID
102867603
Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
713 KB
Volume
47
Category
Article
ISSN
0020-7136

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✦ Synopsis

The targeted radiotherapy of neuroblastoma with l3Illabelled metaiodobenzyl guanidine (mlBG) IS now the subject of several clinical studies. The precise intracellular localization of mlBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electronenergy-loss spectroscopy and electron spectroscopic imaging to establish the intracellular distribution of mlBG in cells from the human neuroblastorna line NBI-G which had been incubated with the drug by mapping iodine in ultra-thin sections of tumours. Most of the iodine is found within the mitochondria, with lesser amounts in the vesicles and on the nuclear membrane. The use of alternative radionuclides with different physical characteristics has been suggested to optimize the efficacy of this therapeutic strategy. The lack of penetration of mlBG into the nucleoplasm means that ultrashort-range Auger electron emitters such as lZ5l are not likely to prove more cytotoxic than l3Il.

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