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Intracellular localization and content of YB-1 protein in multidrug resistant tumor cells

✍ Scribed by A. V. Vaiman; T. P. Stromskaya; E. Yu. Rybalkina; A. V. Sorokin; S. G. Guryanov; T. N. Zabotina; E. B. Mechetner; L. P. Ovchinnikov; A. A. Stavrovskaya

Book ID
110153552
Publisher
Springer
Year
2006
Tongue
English
Weight
280 KB
Volume
71
Category
Article
ISSN
0006-2979

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✍ Rajae Belhoussine; Hamid Morjani; Serguei Sharonov; Dominique Ploton; Michel Man πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 972 KB

Multidrug-resistant cells are believed to contain a plasmamembrane-efflux pump which is hypothesized to expel anticancer drugs from the cytosol to the cell exterior. Many of these drugs are classified as weak bases whose binding to intracellular targets is pH-dependent. Slight alterations in intrace