Protein phosphatase 1 (PP1) is a gene family with a number of important functions in brain. Association with a wide variety of regulatory/targeting subunits is thought to be instrumental in directing the phosphatase to specific subcellular locations and substrates. By using antibodies directed again
✦ LIBER ✦
Subcellular localization of intracellular protein tyrosine phosphatases in T cells
✍ Scribed by Anette Gjörloff-Wingren; Manju Saxena; Shulin Han; Xiaodong Wang; Andres Alonso; Marta Renedo; Phil Oh; Scott Williams; Jan Schnitzer; Tomas Mustelin
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 193 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Abstract CD4 binds to MHC class II molecules and enhances T‐cell activation. The CD4‐related transmembrane protein LAG‐3 (lymphocyte activation gene‐3, CD223) binds to the same ligand but inhibits T‐cell proliferation. We have previously shown that LAG‐3 cell surface expression is tightly regula