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Intracellular IL-1 replaces signaling by the membrane IL-1 type I receptor

✍ Scribed by Werner Falk; Robert Hofmeister

Book ID
116172609
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
162 KB
Volume
6
Category
Article
ISSN
1043-4666

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πŸ“œ SIMILAR VOLUMES

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The IL-1 receptor type I is the ligand-binding chain of the IL-1 heterodimer complex. It is a three-domain Ig-like extracellular receptor with a cytoplasmic domain containing the Toll protein-like sequences. The IL-1 R type I does not function without the second chain of the dimer, namely the IL-1R

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Three molecular forms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1ra type II (IL-1ra3), have no lea