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Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway

โœ Scribed by Iona Evans; Steven K. Dower; Sheila E. Francis; David C. Crossman; Heather L. Wilson

Book ID
116397704
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
280 KB
Volume
33
Category
Article
ISSN
1043-4666

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โœ Marta Muzio; Nadia Polentarutti; Fabio Facchetti; Giuseppe Peri; Andrea Doni; Ma ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 168 KB

Three molecular forms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1ra type II (IL-1ra3), have no lea