## Abstract Iejimalides are novel macrolides that are cytostatic or cytotoxic against a wide range of cancer cells at low nanomolar concentrations. A recent study by our laboratory characterized the expression of genes and proteins that determine the downstream effects of iejimalide B. However, lit
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Intracellular apoptosis-inducing factor is induced by a vacuolar type H+-ATPase inhibitor in B lineage cells
โ Scribed by Shinichi Hashimoto; Akira Ishisaki; Kenji Yamato; Katsuya Aiko; Teruo Amagasa; Tatsuji Nishihara
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 192 KB
- Volume
- 186
- Category
- Article
- ISSN
- 0021-9541
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Tumor necrosis factor (TNF) induces the synthesis o i two proteins of M, 42 and 36 kDa in human fibroblasts and SK-MEL-109 melanoma cells. To identify these proteins, a hgtl0 cDNA library was prepared from the mRNA of TNF-treated SK-MEL-109 cells. By screening this library, we found a cDNA that pref