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Intracellular and cell-surface distribution of amyloid precursor protein in cortical astrocytes

โœ Scribed by Michael J Young; Robert K.K Lee; Sonal Jhaveri; Richard J Wurtman


Book ID
117502869
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
359 KB
Volume
50
Category
Article
ISSN
0361-9230

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Previous reports have shown that exposure of vascular endothelial and smooth muscle cells to exogenous amyloid beta (Aโค) peptide results in cell damage and toxicity via oxidative injury. In this study we demonstrate that overexpression of the amyloid precursor protein (APP) is toxic to bovine aortic