Intra-arterial methotrexate in head and neck tumors
β Scribed by J.M. Richard; H. Sancho; J. Brugere; C. Vandenbrouck
- Book ID
- 113145339
- Publisher
- Elsevier Science
- Year
- 1973
- Weight
- 379 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0014-2964
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Fifty-two consecutive patients, affected by large T2 (>3 cm), T3, T4, NO, or N1 previously untreated squamous cell carcinoma of the head and neck, entered this phase 1-11 study. Treatment consisted of a continuous 8-day infusion on the following daily schedule: cisplatin 25 mg and bleomycin 15 rng a
During the 10-year period from 1966-1975, 250 patients with various head and neck cancers were treated by intra-arterial chemotherapy using single agents or various combinations. Only 15 patients showed response of I-C category according to Karnofsky's criteria, and 100 patients had I-B response. An