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Induction intra-arterial cisplatin and bleomycin in head and neck cancer

✍ Scribed by Dr. Sergio Frustaci; Luigi Barzan; Giuseppe Caruso; Riccardo Ghirardo; Silva Foladore; Antonino Carbone; Yroberto Comoretto; Italo Serafini; Silvio Monfardini

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
658 KB
Volume
13
Category
Article
ISSN
1043-3074

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✦ Synopsis

Fifty-two consecutive patients, affected by large T2 (>3 cm), T3, T4, NO, or N1 previously untreated squamous cell carcinoma of the head and neck, entered this phase 1-11 study. Treatment consisted of a continuous 8-day infusion on the following daily schedule: cisplatin 25 mg and bleomycin 15 rng administered for 4 and 20 hours, respectively. Technical-related toxicities were 1 case each of coagulation and displacement of the catheter and 1 case of reversible monoparesis of the contralateral arm. Drugrelated relevant toxicities accounted for 4 cases of grade 3 or 4 leukopenia and 2 cases of peripheral palsy of the 7th and 12th cranial nerve, respectively. Forty-five of 50 evaluable patients obtained an objective response. In particular, 13 patients obtained a complete response, 22 a partial response 275%, and 10 a partial response 250%. Furthermore, 5 of 31 patients showed a complete pathologic disappearance of the tumor, whereas in 12 of 31 only a microscopic residue was found.

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