Intra-arterial mannitol infusion in the chemotherapy for malignant brain tumors
β Scribed by Yasuo Iwadate; Hiroki Namba; Takashi Saegusa; Kanji Sueyoshi
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 680 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND The treatment of malignant brain tumors is hampered by the presence of the bloodβbrain barrier, which limits chemotherapy penetration to the central nervous system (CNS). In recent years, different strategies have been designed to circumvent this physiologic barrier. The
We have used intra-arterial (i.a.) 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) either alone or as part of adjuvant chemotherapy in patients with malignant brain tumors over a 3 year period (1979-1982). The i.a. BCNU technique was used 111 times to infuse 134 arteries in 37 patients. These patients,
Twelve patients with advanced locoregional (Stage III and IV) squamous cell carcinoma of the oral cavity and oropharynx underwent treatment with cisplatin, vinblastine, bleomycin, and 5-fluorouracil, given by intra-arterial infusion, as primary adjuvant therapy, in preparation for radiation therapy