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Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions

✍ Scribed by Zakeri-Milani, Parvin; Valizadeh, Hadi

Book ID
127322780
Publisher
Informa plc
Year
2014
Tongue
English
Weight
374 KB
Volume
10
Category
Article
ISSN
1742-5255

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The intestinal efflux pump, P-glycoprotein (P-gp), located in the apical membranes of intestinal absorptive cells, can reduce the bioavailability of a wide range of drugs which are substrates for this membrane transporter. In addition to anticancer and anti-HIV drugs, NCEs for other disease indicati