Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding
✍ Scribed by Seelig, Anna; Gerebtzoff, Grégori
- Book ID
- 115490790
- Publisher
- Informa plc
- Year
- 2006
- Tongue
- English
- Weight
- 322 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1742-5255
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The role of P-glycoprotein in mediating the drug-resistance phenotype in multidrug resistant cells is now well documented. It is thought to function as an energy-dependent drug-efflux pump of broad specificity. Structurally, P-glycoprotein is an internally duplicated molecule containing two large mu
The intestinal efflux pump, P-glycoprotein (P-gp), located in the apical membranes of intestinal absorptive cells, can reduce the bioavailability of a wide range of drugs which are substrates for this membrane transporter. In addition to anticancer and anti-HIV drugs, NCEs for other disease indicati