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Intestinal secretion of digoxin in the rat

✍ Scribed by James H. Caldwell; Patricia B. Caldwell; Jay W. Murphy; Craig W. Beachler

Book ID
112342544
Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
503 KB
Volume
312
Category
Article
ISSN
0028-1298

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Following i.v. injection of digoxin (1Opg kg-') the ratio between digoxin concentrations in the lumen ofjejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In qu