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Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia

✍ Scribed by Osterloh, Kurt R. S. ;Simpson, R. J. ;Snape, S. ;Peters, T. J.

Publisher
Springer-Verlag
Year
1987
Weight
573 KB
Volume
55
Category
Article
ISSN
1432-0584

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✦ Synopsis

Three days hypoxia (0.5 atm) increased the haemoglobin and haematocrit values in rats paralleled by enhanced intestinal iron absorption. The destination of recently-absorbed iron was primarily the erythropoietic system, viz. bone marrow, spleen and red cells. Total plasma transferrin, was increased by 30%, but no significant changes in mucosal transferrin were found. No increase in labelling of mucosal transferrin by absorbed iron was observed. These results suggest that mucosal transferrin does not play a major role in the regulation of intestinal iron absorption in hypoxia.

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✍ SchοΏ½mann, K. ;Osterloh, K. ;Forth, W. πŸ“‚ Article πŸ“… 1986 πŸ› Springer-Verlag βš– 602 KB

Isolated non blood-perfused intestinal segments from normal and iron-deficient rats were used in vitro. A modification of the luminal perfusion method according to Fisher and Parsons allowed the comparison of iron and transferrin quantities in the serosal fluid at 15 min intervals. Iron transfer in