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Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat

✍ Scribed by Alessandro Menozzi; Cristina Pozzoli; Elena Giovannini; Elvira Solenghi; Daniela Grandi; Silvia Bonardi; Simone Bertini; Valentina Vasina; Gabriella Coruzzi

Book ID: 113586461
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 599 KB
Volume: 552
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2006.08.089

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## Abstract As with cyclooxygenase (COX)‐2, genetic disruption of __COX‐1__ gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in __Apc__ gene‐deficient mice. The present study was designed to investigate the combined effects of COX‐1 and COX