## Abstract For Abstract see ChemInform Abstract in Full Text.
Intersubunit Interactions in Human Cytidine Deaminase
✍ Scribed by S. Vincenzetti; S. Costanzi; G. Cristalli; P. Mariani; B. Quadrini; N. Cammertoni; A. Vita
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 55 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Cell-free extracts of nitrate-grown Penicillium politans NRC-510 catalyzes the hydrolytic deamination of cytidine to uridine. Uridine was chromatographically identified in cell-free extracts. The enzyme exhibited optimum pH and temperature activities at 6.5 and 80 degrees C respectively. Thermal sta
## Abstract Activation‐induced cytidine deaminase (AID) plays a key role in the induction of somatic hypermutation and class switching at the immunoglobulin loci of B lymphocytes. AID overexpression can induce a mutator phenotype in lymphoid and nonlymphoid cell lines, suggesting that AID by itself