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Human Cytidine Deaminase: Understanding the Catalytic Mechanism

✍ Scribed by S. Costanzi; S. Vincenzetti; A. Vita; C. Lambertucci; S. Taffi; R. Volpini; S. Vittori; G. Cristalli

Publisher
John Wiley and Sons
Year
2004
Weight
56 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

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## Abstract Activation‐induced cytidine deaminase (AID) plays a key role in the induction of somatic hypermutation and class switching at the immunoglobulin loci of B lymphocytes. AID overexpression can induce a mutator phenotype in lymphoid and nonlymphoid cell lines, suggesting that AID by itself