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Interspecies pharmacokinetics and in vitro metabolism of SQ109

โœ Scribed by Lee Jia; Patricia E Noker; Lori Coward; Gregory S Gorman; Marina Protopopova; Joseph E Tomaszewski

Book ID
110009042
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
220 KB
Volume
147
Category
Article
ISSN
0007-1188

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โœ Kevin P. Bateman; Laird Trimble; Nathalie Chauret; Jose Silva; Stephen Day; Dwig ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 174 KB

## Abstract Lโ€454,560 is a potent phospodiesterase 4 (PDE4) inhibitor which was identified as a development candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). As part of the discovery of this compound, interspecies __in vitro__ metabolism data was generated usin