Interspecies differences in in vitro thermal inactivation of unliganded hepatic Ah receptor
β Scribed by James P. Landers; Nigel J. Bunce; Jamie S. Nakai; Martha J. Winhall; S.H. Safe
- Book ID
- 119022975
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 153 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0045-6535
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## Abstract Repeated freezing and thawing, the addition of salts, and elevated temperatures all promote the inactivation of the rat hepatic Ah receptor. The reduced availability of bulk water to solvate the protein is proposed to be the factor linking all these routes for inactivation. Prospective
## Abstract In cytosol, the rat hepatic Ah receptor (AhR) appears to exist in two distinct forms (AhR^Ξ±^, AhR^Ξ²^) in similar concentration. The binding of ligand (2,3,7,8βtetrachlorodibenzoβpβdioxin (TCDD)) to AhR^Ξ±^ requires the receptor be in its oligomeric 8β10 to S conformation (bound to other