In vitro thermal inactivation of hepatic Ah receptors from several mammalian species
โ Scribed by Bunce, N.J.; Landers, J.P.; Nakai, J.S.; Winhall, M.J.; Safe, S.H.
- Book ID
- 121908238
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 603 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0887-2333
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## Abstract Repeated freezing and thawing, the addition of salts, and elevated temperatures all promote the inactivation of the rat hepatic Ah receptor. The reduced availability of bulk water to solvate the protein is proposed to be the factor linking all these routes for inactivation. Prospective
Kinetic analysis of the time course of association of [3Hl-2,3,7,8-tetrachlorodibenzo-pdioxin with hepatic cytosol from five rodent species gave additional evidence for differences in the properties of the Ah receptor ligand binding subunit between species. A parallel study of the association of six