𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Interspecies difference in drug protein binding - temperature and protein concentration dependency: Effect on calculation of effective protein fraction

✍ Scribed by Yasutaka Igari; Yuichi Sugiyama; Shoji Awazu; Manabu Hanano


Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
522 KB
Volume
70
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Determination of unbound drug concentrat
✍ Zhisong Liu; Famei Li; Yuesheng Huang πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 52 KB πŸ‘ 2 views

The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein-drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis

Metal affinity protein precipitation: Ef
✍ Harish V. Iyer; Todd M. Przybycien πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 883 KB

Previous work by u s and others h a s shown that mixing impacts apparent protein solubility in single protein precipitations. In this work, w e probe the effects of contacting conditions on fractional precipitation behavior at the bench scale. We have chosen metal affinity precipitation a s o u r mo

Differential scanning calorimetry of alb
✍ Clifford B. Bleustein; Michael Sennett; Robert T.V. Kung; Diane Felsen; Dix P. P πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 99 KB πŸ‘ 2 views

Background and Objective: Understanding albumin solder denaturation is important for laser tissue soldering. Human (HSA), bovine (BSA), porcine (PSA), and canine (CSA) albumin both fatty acid containing (FAC) and fatty acid free (FAF) were evaluated by using differential scanning calorimetry (DSC).

On the calculation of the concentration
✍ Leonid M. Berezhkovskiy πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 161 KB πŸ‘ 1 views

The measurement of the unbound drug fraction in plasma is routinely performed at drug concentrations much less than that of plasma proteins. Commonly, the protein has several binding sites of different affinities. The obtained value of the unbound drug fraction does not yield the affinity of each bi