Interruption of pregnancy by 5-azacytidine
✍ Scribed by M. Svatá; K. Raška; F. Šorm
- Book ID
- 112647071
- Publisher
- Springer
- Year
- 1966
- Tongue
- English
- Weight
- 89 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1420-682X
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Azacytidine 5'-monophosphate (S-aza-CMP) was synthesized enzymatically from 5-azacytidine (S-aza-C) in a reaction catalyzed by uridine-cytidine kinase. In a second step, 5-azacytidine 5'-triphosphate (5-aza-CTP) was synthesized enzymatically from 5-aza-CMP using CMP kinase and nucleoside diphosphoki
The 5-ACR (5-azacytidine) introduced in human lymphocyte cultures induces a lack or a delay of condensation of some chromosome segments corresponding to the G-bands. The resulting R-banding is very similar to that obtained with a 7-h treatment by BrdU, although the segmentation may be much stronger
## Abstract 5‐Azacytidine 5′‐triphosphate (5‐aza‐CTP) inhibited the phosphorylation of uridine, cytidine, and 5‐azacytidine (5‐aza‐C) in a reaction catalyzed by uridine‐cytidine kinase. The inhibition appeared to be competitive with respect to the adenosine 5′‐triphosphate and noncompetitive with r